Ace Therapeutics has a dedicated team in the field of phages. With more than a decade of research experience, they are able to provide scientific and professional services to our clients worldwide.
Phages have many features such as non-infectivity to mammalian cells, small genome, simple structure, easy engineering, and other advantages, which have attracted the attention of scientists in numerous fields. We especially focus on the application of phages in the field of drug delivery. Through more than ten years of exploration and practical experience, we have established a comprehensive service system for the development of phage-based drug delivery systems.
Fig. 1 3 approaches to phage-based drug delivery development (Ju Z, et al.,2017)
What Can We Do?
Phage-Based Drug Delivery System Development Targeting the Liver
Based on our extensive hands-on experience and multiple validations, Ace Therapeutics aims to maximize the potential of phage-based liver-targeted drug delivery. Facilitate your research projects with our comprehensive and professional services.
- Phage-Based Target-Recognizing Peptide Discovery
We offer comprehensive services in phage-based target-recognizing peptide discovery to facilitate research in the phage-based development of drug delivery systems.
- Construction of phage display libraries: Kunkel mutagenesis, PCR reactions and ligation, codon sets reduction, incorporation of unnatural amino acids, and other techniques
- Uses of targeted peptides: cell targeting drug carriers, directed location of gene delivery vectors, targeting and tissue penetration of nanoparticles
- Filamentous Phage-Based Drug Delivery System Development
Therapeutic cases using filamentous phages to deliver genes, antibodies, compounds, and other drugs have been reported for a long time. Based on previous cases and our practical experience, we have established a series of services to facilitate research on phage-based drug delivery systems.
We use different strategies to enhance the efficiency of phage-based gene delivery, including but not limited to
- Modifying filamentous phages using genetic engineering to enhance their targeting
- Combining the superior properties of eukaryotic viruses with phages to enhance their gene transfer efficiency
- Combining recombinant phage with cationic polymers to enhance gene transfer
We use different strategies to enhance the efficiency of phage-based drug delivery, including but not limited to
- Chemical modification of phage using the chemical group to mitigate the toxic effects of drug candidates
- Modification of phages with cytotoxic drugs to enhance the killing effect of antibody drugs on cancer cells
- Using phages to protect drugs from degradation
- Use of phage-liposome complexes to significantly enhance drug delivery efficiency and cancer cell killing
Ace Therapeutics has extensive hands-on experience in phage-based drug delivery system development. We have a dedicated team to work on this. We can provide high-quality data and a fast turnaround time to support your research project If you would like to learn more about our services, please feel free to contact us.
Reference
- Ju, Z., Sun, W. Drug delivery vectors based on filamentous bacteriophages and phage-mimetic nanoparticles. Drug Deliv, 2017. 24(1): p. 1898-1908.
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