Ace Therapeutics has extensive research experience in the field of liver disease drug development. We aim to provide a one-stop drug development platform for liver disease drug developers worldwide.
Introduction to Natural Compound for the Treatment of Liver Disease
As natural compounds are intensively researched, more and more natural compounds are showing therapeutic effects on liver disease. These natural compounds can be used in a variety of ways including antioxidant, anti-inflammatory, and protective effects for the treatment of liver disease.
Figure 1. Hepatoprotective effects of different flavonoids. (Liao Y., et al. 2024)
What Can We Do?
Natural compounds are a vast treasure trove of promising drug candidates. We offer a comprehensive research service for the therapeutic potential of different natural compounds for liver disease.
Development of Flavonoids for Liver Disease
We provide comprehensive preclinical services to evaluate the therapeutic effects and mechanisms of flavonoids on liver diseases.
| Item |
Service Detail |
| Regulation of Intestinal Microbes |
- Evaluate the effect of flavonoid compounds on the organism's intestinal flora by 16S RNA, fluorescent quantitative PCR, and other techniques.
- Examine the effect of flavonoid compounds on intestinal barrier function by intestinal permeability assay, plasma diamine oxidase activity assay, and intestinal bacterial translocation.
- Combine metabolomics and microbiomics techniques to detect the effects of flavonoid compounds on the levels of bacterial metabolites.
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| Regulation of Oxidative Stress |
- Test antioxidant enzymes and indicators of reactive oxygen species to assess the effect of flavonoids on oxidative stress in the course of liver disease.
- Study oxidative stress-related signaling pathways to assess the effect of flavonoids on the body's ability to resist oxidative stress.
- Detect typical inflammatory pathways and cytokines by PCR, western blotting, and other assays to evaluate their therapeutic effect on liver disease.
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Development of Terpenoids for Liver Disease
Given the multiple activities of terpenoids, we offer comprehensive research services to develop terpene drug candidates for liver disease.
- Evaluate the hepatoprotective effects of the drug candidates by examining the effects of terpenoids on hepatocyte regeneration, hepatic lipid peroxidation, and other processes.
- Screen endoplasmic reticulum stress-related genes by gene microarray technology to further investigate the mechanism of action of terpenoids in treating liver disease by inhibiting endoplasmic reticulum stress.
- Evaluate the therapeutic effect of terpenoids on liver disease through inhibition of apoptosis by morphological examination, phosphatidylserine exocytosis analysis, and detection of mitochondrial membrane potential and DNA fragmentation assay.
Ace Therapeutics has extensive research experience in the field of natural drug development for liver diseases. Based on our professional scientists and rich practical experience, we aim to provide you with the most professional drug development services. If you would like to learn more about our services, please feel free to contact us.
Reference
- Liao Y., et al. Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities. Front Pharmacol. 2024, 15:1485065.
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