Ace Therapeutics provides comprehensive solutions for clients worldwide developing hydrogen molecular (H2) therapies to treat liver disease. Our services focus on exploring the specific mechanisms by which H2 therapy plays a role in liver disease to reveal the specific roles it plays.
Since H2 was shown to inhibit the growth of squamous carcinoma in mice, scientists have discovered its protective effects against various diseases such as cancer, organ damage, etc. H2 acts as an excellent natural antioxidant and free radical scavenger to regulate the inflammatory response, gene regulation, and apoptosis. Studies have proven that H2 can effectively alleviate liver diseases such as liver injury and non-alcoholic steatohepatitis. We offer comprehensive services for H2 to fully explore the role of H2 therapy in liver disease.
What Can We Do?
Hydrogen Therapy Development Services for Liver Disease
The therapeutic effects of H2 in liver disease have been established, but its specific mechanism of action is unclear. We provide comprehensive services for the therapeutic effects of H2 to explore its specific mechanism of action and to explore better ways of drug delivery.
- Preclinical Evaluation of Drug Candidates for the Treatment of Liver Disease
According to the present findings, H2 exerts its curative effects mainly through antioxidant and anti-inflammatory effects. Therefore, we mainly investigated the therapeutic effects of H2 on liver disease from two perspectives: antioxidant and anti-inflammatory. Meanwhile, we performed a high-throughput analysis of the therapeutic process of H2 by gene microarray and protein microarray methods to obtain more pathways of the mechanism of action.
- Anti-inflammatory effect of H2 on liver disease treatment
- Antioxidant effect of H2 on liver disease treatment
- Anti-apoptotic effect of H2 on liver disease treatment
- High-throughput analysis
- Hydrogen Therapy Delivery Systems
H2, being a small molecular gas, can diffuse into the target tissue without any hindrance. Therefore, H2 can currently act by inhalation, by invoking H2-rich water or H2-rich saline, etc. However, different effects occur with different concentrations of H2. Therefore, maximizing the use of H2 for the treatment of liver disease still requires the development of more appropriate delivery routes.
We have conducted an in-depth investigation for hydrogen therapy based on nanocarrier materials to develop and improve new approaches through the exploration of scientists in different fields.
- Nanomaterials can be used as H2 generators while showing high H2 storage efficiency.
- The non-invasive nature of photocatalysis is suitable for the development of new photocatalytic nanomaterials for H2 therapy.
- X-rays can compensate for the drawbacks of photocatalysis
Ace Therapeutics also provides additional services to support the development of H2 therapies for liver disease in a comprehensive manner. If you would like to learn more about our services, please feel free to contact us.
Reference
- Shi, J., et al., Hydrogen treatment: A novel option in liver diseases. Clin Med (Lond), 2021. 21(2): p. e223-e227.
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