Ace Therapeutics provides solutions for developing hepatocyte therapies for liver diseases for clients worldwide. With our expert scientists and ten years of hands-on experience, we can provide targeted assistance to accelerate the development of your hepatocyte therapy program.
In liver disease, the primary goal of cellular therapy is to replace damaged liver cells with healthy ones, and transplantation of primary liver cells is the simplest and most direct method. Clinical studies have shown that a patient with liver disease recovered completely after receiving hepatocyte therapy, which confirms the feasibility of hepatocyte therapy for liver disease. We have extensive experience in hepatocyte therapy and can help you solve all the difficulties and problems encountered in the process of hepatocyte therapy research.
What Can We Do?
Hepatocyte Therapy Development for the Treatment of Liver Disease
We offer targeted solutions for all aspects of the hepatocyte therapy development process. From the source of hepatocytes to the selection of the transplantation route, we offer you the best scientific services thanks to our experience and expertise.
- The Source of Hepatocytes
In clinical practice, there are 3 main sources of stem cells, which are donor stem cells, differentiated from induced pluripotent stem cells, and finding replacement hepatocytes. We have strict control over the source of hepatocytes. We have perfected hepatocyte isolation techniques to ensure the quality and quantity of isolated hepatocytes. We have established and are continuously optimizing our cell preservation methods to minimize the effect of cryopreservation on cell activity. The search for an alternative hepatocyte source is xenotransplantation of animal-derived hepatocytes. Porcine cells are currently widely studied and we offer specialized services.
- Mechanical separation method
- EDTA chelation method
- TPB chelation method
- Enzymatic digestion
- Choice of Transplant Route
Currently, liver cells are transplanted into the portal vein, abdomen, and spleen. Our scientists develop the appropriate study protocol for you based on the actual study project while providing you with the most scientific service.
- Intra-abdominal hepatocyte transplantation
The technique is simple, but the implanted hepatocytes are susceptible to sensitization and most are removed within 3 days.
- Intra-splenic parenchymal transplantation
Hepatocytes implanted in the spleen can survive for a long time, proliferate, and maintain the morphology and function of the hepatocytes with a dramatic increase in survival time
In addition, hepatocytes can be implanted through the pancreas, lung, renal fat capsule, subcutaneous tissue, and muscle, all of which have some metabolic support, but none of them are as effective as intrasplenic transplantation.
Ace Therapeutics has a dedicated team in the development of hepatocyte therapies. With our hands-on experience, we provide you with the most professional and appropriate service solutions. For immune rejection and proliferative activity of transplanted hepatocytes, we also offer comprehensive testing services. If you would like to learn more about our services, please feel free to contact us.
Reference
- Nicolas, C. T., et al., Cell therapy in chronic liver disease. Curr Opin Gastroenterol, 2016. 32(3): p. 189-194.
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