Ace Therapeutics is committed to providing the most professional services to liver disease researchers worldwide. With our expertise and experience in exosome-based liver disease drug delivery systems development, we can escort your research.
As nanocarriers, exosomes have many unique advantages in drug delivery, such as similarity to cell membranes, small size, negative charge, avoidance of phagocytosis, generation of immune escape, long circulation time, and ability to penetrate deep tissues. Therefore, it is an ideal natural nanocarrier for drug delivery. We have extensive research experience in the field of exosome-based drug delivery and our services have been validated by multiple parties, aiming to provide you with the most professional liver-targeted exosome delivery services.
What Can We Do?
According to the structural characteristics of exosomes, we mainly provide two ways of drug delivery, namely active loading and passive loading. Our scientists will choose the right load for you according to your experimental characteristics, research needs, and the structural characteristics of the liver.
Active Loading
- Commonly used active loading methods are ultrasound, extrusion, repeated freeze-thaw, and electroporation.
Passive Loading
- There are two main ways of passive loading. One is to incubate the drug with exosomes, and the other is to co-incubate the drug with exosome donor cells so that the cells secrete the desired exosomes.
- Delivery Mode for Different Drug Types
According to the structural characteristics of exosomes and the liver, we mainly provide two ways of drug delivery, namely active loading and passive loading. Our scientists will choose the right loading for you according to your experimental characteristics and research needs.
- For siRNA drugs, we generally load them by electroporation, chemical transfection, sonication, and cellular overexpression.
- For miRNA drugs, we generally load by chemical transfection, cellular overexpression, fusion expression, and electroporation.
- For mRNA drugs, we generally load by cellular overexpression, electroporation, fusion expression, and nanoperforation.
- For DNA drugs, we generally recommend transfection of source cells and electroporation for loading.
- For small molecule drugs, we generally load by co-incubation, electroporation, sonication, source cell loading, chemical transfection, extrusion, repeated freeze-thaw, and low osmotic pressure.
- For protein drugs, we generally load them by electroporation, chemical transfection, extrusion, ultrasound, cholesteryl ester anchor linkage, cellular overexpression, EV marker protein fusion expression, and protein-protein interactions.
- For lipid drugs, we generally load them by fusing them with liposomes followed by repeated freeze-thawing and co-incubation.
Ace Therapeutics has extensive research experience in the field of exosome-based delivery systems for the development of liver disease drugs. Our service has been verified by many parties, and the test results are stable and reliable. If you would like to learn more about our services, please feel free to contact us.
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
