Ace Therapeutics provides comprehensive solutions to customers worldwide to develop drugs against liver cancer. Our scientists have a decade of research experience in the field of liver cancer drug development and can provide you with expert and authoritative opinions and solutions.
Many methods have been developed to treat cancer by killing cancer cells, including natural compounds, chemotherapeutics, and immunotherapy, but they are still not effective in controlling the pathological process of liver cancer.
What Can We Do?
Although there are many therapies available for liver cancer, they are still not effective in curbing the progression of liver cancer. Based on our rich experience and advanced technology, we are committed to providing you with comprehensive therapeutic development services for liver cancer in order to facilitate the research progress of liver cancer therapeutic development.
- Immunotherapy for Liver Disease
Liver cancer affects the body's immune system in several ways; therefore, immunotherapy is one of the most promising ways to treat liver cancer. There are two main underlying principles of immunotherapy, one is the ability to reveal the current immune response and the other is the need to stimulate new or different immune responses. We offer targeted services to meet the needs of different research projects based on the characteristics of different immunotherapies.
- Immune Checkpoint Inhibitors
Immune checkpoints such as programmed cell death protein 1, cytotoxic T-lymphocyte associated antigen 4, T-cell immunoglobulin and mucin-domain containing-3, transforming growth factor-β, and lymphocyte activation gene 3 have been used in clinical trials for hepatocellular carcinoma.
- Adoptive Cell Transfer
Adoptive cell transfer aims to improve the outcome of liver cancer by passively administering autologous lymphocytes after in vitro culture. NK cells, CIK cells, antigen-specific T cells, and chimeric antigen receptor T cells have all been used in relay cell transfer therapy.
- Vaccines
Tumor vaccines are used to treat tumors by increasing the specific immune response to tumor antigens. Dendritic cells, peptide vaccines, and oncolytic viruses have all been used in the development of tumor vaccines.
- Combining Immune and Targeted Therapies Liver Disease
By combining immunotherapy and targeted therapy in the treatment of liver cancer, better therapeutic effects can be achieved. The combination of anti-CTLA4 and anti-PD1 or anti-CTLA4 and anti-PDL1 is also being conducted for the treatment of hepatocellular carcinoma. We also provide high-quality and comprehensive research services for this treatment modality.
- We will provide in vitro and in vivo models of different liver cancer.
- We will perform a preliminary assessment of the therapeutic efficacy of the combination of different therapies, including tyrosine kinase inhibitors, cell cycle inhibitors, anti-VEGF agents, etc.
- We will evaluate the therapeutic efficacy by different biomarkers.
- We will assess the extent of liver damage by pathological examination techniques.
There are many types of liver cancer, and Ace Therapeutics provides targeted services according to different types of liver cancer. We have more than ten years of practical experience in liver cancer drug development and can provide you with the most professional and appropriate technical service support. If you would like to learn more about our services, please feel free to contact us.
Reference
- Greten, T. F., et al., Targeted and immune-based therapies for hepatocellular carcinoma. Gastroenterology, 2019. 156(2): p. 510-524.
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