Ace Therapeutics is an expert in the field of liver disease drug development. We aim to provide the most professional research services to liver disease drug development investigators worldwide.
Introduction to the Role of Hepatic stellate cell (HSC) in Liver Disease
Hepatic stellate cells (HSCs) play a pivotal role in liver disease pathogenesis. In healthy livers, HSCs store vitamin A. However, upon injury, they transform into myofibroblast-like cells, driving liver fibrosis. This activation leads to the excessive production of extracellular matrix proteins, disrupting liver architecture and function. Targeting HSC activation is thus a key therapeutic strategy for combating liver fibrosis and its progression to cirrhosis.
Figure 1. HSC activation is critical in the development and progression of liver fibrosis. (Tan Z. et al. 2021)
What Can We Do?
Stellate cells, especially hepatic stellate cells, play an important regulatory role in the development of liver disease. Therefore, based on our rich research experience and advanced technology platform, we provide comprehensive drug development services for liver diseases targeting stellate cells.
- Drug Development Targeting the Role of Stellate Cells in Liver Regeneration for Liver Disease
Given that the liver is the only solid organ capable of maintaining a stable organ-to-body weight ratio using regenerative mechanisms to restore homeostasis in the body after injury, we should take full advantage of the liver's regenerative mechanisms to restore its function when developing drugs to treat liver disease.
- We will provide gene microarray technology, protein microarray technology, single cell sequencing, and other assays to develop more in-depth target identification for existing studies.
- Given the role of hepatic stellate cells in driving liver regeneration through the secretion of growth factors, we will offer a complete service to screen for growth factor-based modulators of liver regeneration.
- Given the role of hepatic stellate cells in driving liver regeneration through the secretion of cytokines, we will offer a complete service to screen for cytokine-based regulators of liver regeneration.
- In view of the role of hepatic stellate cells in promoting liver regeneration by paracrine signaling, we will offer a complete service to screen for modulators based on paracrine signaling for liver regeneration.
- Drug Development Targeting Stellate Cells-Mediated Immune Response for Liver Disease
Stellate cells are important mediators of hepatic immunomodulation, which induce a variety of immune cells to regulate inflammation. In view of this, we offer well-established services for developing liver disease drugs targeting the immunomodulatory effects of stellate cells.
- For the elicitation of different leukocytes by stellate cells, we will offer a complete screening and evaluation service for inhibitors targeting leukocytes.
- For the modulation of stellate cells at pattern recognition receptors, we will provide extensive screening and further evaluation services for pattern recognition receptor modulators by gene microarray and protein microarray technologies.
- For the modulation of chemokines by stellate cells, we will provide extensive screening of different modulators for the specific role of chemokines in different liver diseases and their in-depth evaluation by WB, ELISA, IHC, and other assays.
Ace Therapeutics has extensive research experience in the field of liver disease drug development. Our team is committed to providing you with the most professional and scientific liver disease drug development services. If you have any comments or questions, please contact us so we can help you better.
Reference
- Tan Z. et al. Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy. Front Cell Dev Biol. 2021, 9:730176.
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