Ace Therapeutics has extensive research experience in the field of liver disease drug development, and we aim to provide the best match for investigators in liver disease drug development worldwide to facilitate the progress of liver disease drug research.
Macrophages are important immune cells in innate immunity and play an important role in the pathological process of liver disease. Therefore, regulating macrophage activity and function is an important way to treat liver disease. Based on our professional scientists and advanced technology platform, we aim to provide you with unparalleled drug development services targeting liver diseases.
What Can We Do?
Given that macrophages are important immune cells in the development of liver disease and regulate the pathological process of liver disease, we offer comprehensive drug development services to support your research by targeting the different regulatory activities of macrophages.
- Drug Development Targeting Macrophage Polarization for Liver Disease
Since the progression of liver disease induces different phenotypes of macrophage polarization and thus regulates the signaling pathways, adjustment of macrophage polarization can regulate the progression of liver disease and thus achieve the goal of treating liver disease.
- Given that macrophage polarization is regulated by multiple signaling pathways, we will provide drug screening services for liver disease treatment by targeting these regulators to modulate the macrophage polarization process.
- Given the way miRNAs can regulate macrophage polarization, we will offer services to discover active miRNAs and screen for effective regulators to treat liver disease by high-throughput sequencing technologies such as PCR microarrays.
- Given the pro-inflammatory role of M1 macrophages, we will screen extensively for inhibitors targeting the M1 macrophage polarization process based on our compound library.
- Given the anti-inflammatory role of M2 macrophages, we will conduct an extensive screening of agonists targeting the polarization process of M2 macrophages based on our compound library.
- Drug Development Targeting Macrophage-Mediated Inflammatory&Immune Response for Liver Disease
Given that macrophages regulate inflammation and immunity in physiological and pathological states, we can modulate the inflammatory and immune responses induced by macrophages in order to regulate the body state and thus treat liver diseases. Accordingly, we provide a comprehensive service to support research in the development of drugs for liver disease.
- For the regulatory role of macrophages on inflammatory factors, we provide services for the discovery of inflammatory factor modulators based on the macrophage pathway to inhibit inflammation.
- For the role of macrophages in releasing cytotoxic molecules to kill damaged hepatocytes, we provide services to screen for modulators that regulate the activity of macrophages in releasing cytotoxic molecules.
- In response to the pro-inflammatory and pro-tumor activities of macrophages, we provide screening and evaluation services for regulators that inhibit the origin and aggregation of macrophages and thus hepatocellular carcinoma.
Ace Therapeutics has extensive hands-on experience in the field of drug development for liver diseases. Our professional team will develop an appropriate service plan for you based on your study needs and trial protocol to facilitate the smooth conduct of your study. You can contact us by email, and we will arrange for a staff to contact you as soon as possible!
Reference
- Dou, L., et al., Macrophage phenotype and function in liver disorder. Front Immunol. 2019. 10: p. 3112.
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