Ace Therapeutics is an expert in the field of liver disease. With our extensive hands-on experience, we aim to provide a one-stop research platform for liver disease researchers.
Introduction to the Role of EGFR in Liver Disease
Studies have shown that epidermal growth factor (EGFR) plays an important role in liver regeneration after acute, chronic liver injury, cirrhosis, hepatocellular carcinoma, and other liver diseases. This suggests that EGFR is a potential therapeutic target for liver disease.
Figure 1. The Role of EGFR in liver injury and disease. (Komposch K, Sibilia M. 2015)
What Can We Do?
Natural compounds are a vast treasure trove of promising drug candidates. We offer a comprehensive research service for the therapeutic potential of different natural compounds for liver disease.
Development of Flavonoids for Liver Disease
We provide comprehensive preclinical services to evaluate the therapeutic effects and mechanisms of flavonoids on liver diseases.
| Item |
Service Detail |
| Regulation of Intestinal Microbes |
- Evaluate the effect of flavonoid compounds on the organism's intestinal flora by 16S RNA, fluorescent quantitative PCR, and other techniques.
- Examine the effect of flavonoid compounds on intestinal barrier function by intestinal permeability assay, plasma diamine oxidase activity assay, and intestinal bacterial translocation.
- Combine metabolomics and microbiomics techniques to detect the effects of flavonoid compounds on the levels of bacterial metabolites.
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| Regulation of Oxidative Stress |
- Test antioxidant enzymes and indicators of reactive oxygen species to assess the effect of flavonoids on oxidative stress in the course of liver disease.
- Study oxidative stress-related signaling pathways to assess the effect of flavonoids on the body's ability to resist oxidative stress.
- Detect typical inflammatory pathways and cytokines by PCR, western blotting, and other assays to evaluate their therapeutic effect on liver disease.
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Development of Terpenoids for Liver Disease
Given the multiple activities of terpenoids, we offer comprehensive research services to develop terpene drug candidates for liver disease.
- Evaluate the hepatoprotective effects of the drug candidates by examining the effects of terpenoids on hepatocyte regeneration, hepatic lipid peroxidation, and other processes.
- Screen endoplasmic reticulum stress-related genes by gene microarray technology to further investigate the mechanism of action of terpenoids in treating liver disease by inhibiting endoplasmic reticulum stress.
- Evaluate the therapeutic effect of terpenoids on liver disease through inhibition of apoptosis by morphological examination, phosphatidylserine exocytosis analysis, and detection of mitochondrial membrane potential and DNA fragmentation assay.
Ace Therapeutics has extensive research experience in the field of natural drug development for liver diseases. Based on our professional scientists and rich practical experience, we aim to provide you with the most professional drug development services. If you would like to learn more about our services, please feel free to contact us.
Reference
- Komposch K, Sibilia M. EGFR signaling in liver diseases. Int J Mol Sci. 2015 Dec 29;17(1):30.
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