Ace Therapeutics is an expert in the field of liver disease research. We aim to provide the most professional research services to liver disease researchers worldwide through our professional technology and services.
Genetic liver disease is a metabolic abnormality of liver function caused by genetic variation. The incidence of this disease is low, but the condition is complex and there is a lack of effective treatment.
What Can We Do?
With rich experience in genetic liver disease research and advanced technology platform, we are committed to providing you with the most professional basic research service on genetic liver disease.
- Basic Research Services for Hemochromatosis
Advances in genetics have deepened scientists' knowledge and understanding of iron-related disorders, particularly hemochromatosis. Hemochromatosis is a typical metabolic abnormal disease. We offer a well-established service process based on the pathological features of the disease to meet the needs of different research projects.
- We will perform high-throughput screening of genes associated with hemochromatosis for biomarkers by techniques such as gene microarray technology and protein microarrays.
- We will assess the presence of iron overload in blood by assaying serum transferrin saturation, serum ferritin, and other methods.
- We will perform a validated diagnosis of iron overload by dual-energy CT iron quantification.
- Basic Research Services for Wilson's Disease
WD is an inherited disorder of copper metabolism, which causes pathological copper accumulation in many organs and leads to a variety of symptoms. We have established a perfect service system according to the different pathological mechanisms and pathological characteristics of WD.
- Gene screening
The gene mutation is the main cause of WD. In addition to mutations in ATP7B, PNPLA3, and COMMD1 are also responsible for the disease. Therefore, we will perform high-throughput screening to screen WD-related pathogenic genes.
- Oxidative stress
Oxidative stress is the main cause of liver injury associated with copper accumulation. We will screen for genetic variants associated with antioxidant enzymes and their effects on metabolic pathways to discover more pathogenic mechanisms.
- Copper homeostasis
Copper is a cofactor for many enzymes and participates in key physiological and pathological processes of the body. In WD, the disturbance of copper homeostasis can affect the metabolic pathways of the body. We will screen the metabolic pathways involved in copper and further study its specific pathogenic mechanism.
- Basic Research Services for Alpha-1 Antitrypsin Deficiency
Alpha-1 antitrypsin deficiency is an inherited disease characterized by lung injury and liver abnormalities, and this disease is the most common genetic cause of liver disease in children. We provided comprehensive research services for the characteristics of alpha-1 antitrypsin deficiency.
- We will evaluate the pathological process and pathological development of this disease by constructing the different alpha-1 antitrypsin deficiency models.
- We will evaluate the effect of alpha-1 antitrypsin deficiency on the inflammatory response in the body.
- We will evaluate the liver tissue damage to determine the liver damage caused by alpha-1 antitrypsin deficiency under different pathological conditions.
Ace Therapeutics has extensive research experience in the field of genetic liver disease research. Our service is set up according to the exclusive characteristics of different diseases, through professional and perfect service to bring you the perfect experience. If you would like to learn more about our services, please feel free to contact us.
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Our products and services are for research use only and can not be used for diagnostic or other purposes.
