Ace Therapeutics is an expert in the field of basic research in liver disease. Based on our expertise and technology platform, our team will provide the best service experience for our customers around the world.
The liver is the largest metabolic and detoxification organ of the body, which is extremely vulnerable to the damage of various drugs and metabolites entering the body. Drug-induced liver injury (DILI) is a disease caused by different types of drugs, health products, dietary supplements, and their metabolites, resulting in hepatocyte damage and necrosis, abnormal liver enzymes, and related clinical manifestations.
What Can We Do?
DILI is a common liver disease, most of which are caused by the incorrect use of drugs, and some are related to the body's immune system. Based on our professional knowledge and advanced technology platform, we are committed to providing comprehensive and professional research services and support for DILI researchers.
Drugs themselves or their metabolites may directly cause liver injury, the most common of which is acetaminophen hepatotoxicity. We provide comprehensive testing services for the direct hepatotoxic effects of drugs, including but not limited to
- Measurement of mortality
- Assessment of the extent of liver lesions
- Measurement of mitochondrial damage
- Assessment of cholestasis
- Detection of steatosis
Idiosyncratic DILI is mainly an immune-related injury, which mainly causes hepatocyte damage by activating humoral immunity. The specific mechanism of idiosyncratic DILI is still unclear, and therefore effective treatment is difficult. We provide a comprehensive service targeting the pathological mechanisms of idiosyncratic DILI. Since there is no definitive mechanism, we summarize the potential pathogenesis based on cases of incidental DILI that have occurred. We also provide targeted testing services for these pathogenic mechanisms, including but not limited to
- Assays for mitochondrial function
- Assessment of the autoimmune system
- Assays for stellate cell activation and chronic endothelial cell injury
- Assays for acute endothelial cell injury
- Detection and evaluation of drug hypersensitivity reactions
- Assays for lipid metabolic processes
Drug stress can destroy mitochondrial function, thereby destroying the intrinsic recycling process of the body. We provide different research services according to the characteristics of idiosyncratic DILI, including but not limited to
- We will examine the effect of specific DILI on lipoatrophy.
- We will examine the effect of specific DILI on mitochondrial membrane permeability and mitochondrial membrane potential.
- We will examine the effect of specific DILI on the ability of mitochondria to produce ROS.
Ace Therapeutics has extensive experience in the field of liver disease research. We are committed to contributing our greatest strength to the research progress of DILI. Our professional team will customize the most scientific and appropriate service plan for you according to your project needs. If you would like to learn more about our services, please feel free to contact us.
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Our products and services are for research use only and can not be used for diagnostic or other purposes.
