Ace Therapeutics is an expert in the field of liver disease research. We offer comprehensive development services for different types of liver disease drugs.
Amino acids are the basic substances that make up the proteins needed for human nutrition. Current research has found that supplementation with branched-chain amino acids can be effective in the treatment of cirrhosis, liver fibrosis, and hepatic encephalopathy. Yet related studies are limited. Therefore, we offer a comprehensive service to support the development of amino acid drugs for the treatment of liver diseases.
What Can We Do?
Amino acids, especially branched-chain amino acids, have been shown to have activities that affect gene expression, protein metabolism, hepatocyte apoptosis and regeneration and even inhibit hepatocyte proliferation. Therefore, they have a powerful potential in the treatment of liver diseases. We offer a comprehensive drug development research service for amino acid activities.
Our Capacity
There are 4 main methods of amino acid preparation, namely, natural protein hydrolysis, fermentation, enzyme conversion and chemical synthesis. We provide the corresponding preparation services for the 4 methods.
- Hydrolysis method
We hydrolyze proteins by acids, bases, and enzymes into a variety of amino acid mixtures, which are then separated and purified to obtain a variety of amino acids for medicinal use. Commonly used amino acids produced by hydrolysis include L-cystine, L-arginine, L-leucine, L-isoleucine, L-histidine, L-proline, and L-serine.
- Fermentation method
We use the action of enzymes in microbial cells to convert organic matter in the culture medium into amino acids. We have modified microbial cells using cell fusion technology and genetic recombination technology to cultivate a variety of high-yield amino acid hybrid strains and genetically engineered bacteria for amino acid production.
- Enzyme conversion method
We use the action of specific enzymes to convert certain compounds into the corresponding amino acids. The amino acids commonly produced by enzymatic conversion include DL-methionine, DL-phenylalanine, DL-tryptophan, DL-alanine, and DL-threonine.
- Chemical synthesis method
We can synthesize alpha amino acids through chemical reactions such as ammonolysis, hydrolysis, condensation, substitution, and hydrogenation reduction. The main synthesis methods are general synthesis and asymmetric synthesis.
Our Services
Studies have proven that amino acids have significant therapeutic effects on liver diseases. We offer a comprehensive service to discover amino acids with therapeutic activity. We also offer different modification services and preclinical evaluation of drugs to improve and fully assess the efficacy of drug candidates.
- We have established different methods for the separation of amino acids including but not limited to solubility methods, isoelectric point precipitation, special reagent precipitation, adsorption, and ion exchange methods.
- We refine amino acids by crystallization, recrystallization, and solubility methods.
- We will screen the regulatory processes involved in amino acids by high throughput techniques such as gene microarrays, protein microarrays, etc.
- We provide different drug screening platforms to discover amino acid drugs with potential therapeutic activity.
- We provide different liver disease models for evaluating the therapeutic effects of amino acid drugs.
Based on our research experience in the field of liver disease research, Ace Therapeutics is committed to providing you with high quality and efficient amino acid drug development services. If you would like to learn more about our services, please feel free to contact us.
Related Services
Our products and services are for research use only and can not be used for diagnostic or other purposes.
