Target Identification Service

Generally, there are two scenarios you want to perform a drug identification analysis. The first scenario is you "have a drug of efficacy but the target is unknown". The other is you "need to find a target for new drug discovery and development". Whether you are performing studies on antibody therapy, insulin alternatives or other treatments about diabetes, Ace Therapeutics can provide a full range of services related to diabetes.

A Target-based Drug Discovery Process

When you need to find a target for new drug discovery and development, target identification is also known as target discovery, where a druggable target needs to be established before drug screening. A gene or a biomarker with known functions in diabetes process is identified to generate drug screening assays.

Genes Related to Diabetes
Most genes related to diabetes are related to β-cells function related. The genetic risk of T1DM is mainly based on human leukocyte antigen (HLA) typing, and the most critical gene is HLA class II antigen gene.
Non-genetic Biomarkers of Diabetes
Metabolites can be identified as biomarkers that may be useful for the diagnosis or treatment of diabetes. Metabolites, microRNA or other biomolecules can be biomarkers for diabetes.
Receptors Associated with Diabetes
The receptors associated with diabetes mainly include the insulin receptor, leptin receptor, adipokine, cytokines, etc. The glucagon and GLP-1 receptors are both important drug targets for type 2 diabetes and obesity. These results may help inform the design of new drugs to regulate blood glucose levels.

Fig 2. Use of Epigenetic Profiling of Progenitor Cells and Mature bata-cells in Diabetes Research Use of Epigenetic Profiling of Progenitor Cells and Mature β-cells in Diabetes Research (Nuria, C. B.; et al. Trends in Endocrinology & Metabolism, 2012)

A Phenotype-based Drug Discovery Process

When you have a drug of efficacy but the target is unknown, target identification is also known as target deconvolution, where the determination of the small molecular target is after the drug has been proved to exert the desired effect. Phenotypic discovery is a mechanistic agnostic strategy. Therapeutics are identified by the effect upon a phenotype and subsequently the newly identified therapeutics are used to identify the mechanism of action.

Fig 3. Target Identification and Validation is A Multifunctional Process Target Identification and Validation is A Multifunctional Process

Our Services

It is an extremely important part of the drug development stage to identify and validation the target, confirm the importance of its physiology and pathology. Ace Therapeutics has the expertise, scale and instruments to provide the target identification services. Our services include but not limited to the followings.

Fig 4. Target-based Identification Strategies

Target-based Identification Strategies

We offer strategies to identify new genes or proteins targets and verify whether the genes or proteins of interest are targets for diabetic therapy development.

Fig 5. Phenotype-based Identification Strategies

Phenotype-based Identification Strategies

We are able to identify the molecular target(s) of a drug with unknown/uncertain targets but known/certain efficacy.

Features of Our Services

Highly Customizable

One-stop Services

High Qualitys High Quality

Professional Team

Ace Therapeutics can accelerate the therapeutic development and drug discovery process about diabetes for our clients worldwide. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us.

Reference

Ashcroft, F. M. and Rorsman, P. Diabetes Mellitus and the β Cell: The Last Ten Years. Cell, 2012, 148(6), 1160-1171.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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