Ace Therapeutics provides integrated solutions for preclinical small molecule antidiabetic drug development. Our team of experts with extensive drug development experience can help you accelerate the success of your small molecule antidiabetic drugs from drug discovery to clinical translation. With our one-stop services, we can help you design and conduct efficient and cost-effective studies to accelerate the time-to-market of your antidiabetic drugs.

Introduction of Small Molecule Antidiabetic Drugs

Small molecule drugs provide an important therapeutic option for individuals with diabetes. Several small molecule drugs have been developed and approved for the treatment of diabetes, such as metformin, sulphonylureas and thiazolidinediones. These drugs primarily target insulin resistance and glucose regulation. However, there is still a demand for more effective and targeted small molecule drugs to better manage diabetes.

Small molecule antidiabetic drugs often have good oral bioavailability and targeting properties compared to other types of drugs, and can be effective in combating diabetes and its complications.

Fig. 1 Small molecule drugs to treat T2DM. (Guo, Y. Y. et al., 2024)

Our Small Molecule Antidiabetic Drug Development Services

Ace Therapeutics is committed to developing highly effective antidiabetic drugs with lower side effects for our clients through precise drug design, preclinical screening and evaluation.

• Antidiabetic Drug Discovery Services

Ace Therapeutics has established a rich library of small molecule compounds based on different targets of diabetes. By applying high-throughput screening techniques, we can quickly identify promising seedling compounds from the corresponding libraries. In addition, we provide lead compounds and candidate compounds through a multi-layer structure optimization strategy, and fully evaluate their efficacy and safety.

• Target identification services
• Hit identification services
• Hit-to-lead services
• Lead optimization services
• Antidiabetic drug candidate selection services
• Preclinical Development Services for Antidiabetic Drug

Ace Therapeutics help clients comprehensively assess the efficacy and safety of their small molecule antidiabetic drug candidates with in vivo and in vitro modelling services to accelerate the drug development process.

• Assessment of the efficacy of antidiabetic drugs
• ADME & DMPK studies for antidiabetic drug
• Safety assessment for antidiabetic drug
• Bioanalysis for antidiabetic drug

Fig. 2 Small molecule antidiabetic drug development process.

Our Technologies in Small Molecule Antidiabetic Drug Development

• High throughput screening (HTS)
• Virtual screening
• Structure-based drug design (SBDD)
• In vivo modeling of diabetes mellitus
• In vitro modeling of diabetes mellitus

Ace Therapeutics is committed to providing customized services to meet the specific demands of our clients in the development of small molecule antidiabetic drugs. Please contact us for more details. Our experienced experts will collaborate with you to develop and advance innovations in diabetes therapeutics.

Reference

1. Guo, Y. Y.; et al. A comprehensive review of small-molecule drugs for the treatment of type 2 diabetes mellitus: Synthetic approaches and clinical applications. European Journal of Medicinal Chemistry (2024): 116185.

• Antidiabetic Peptide Drug Development Services
• Protein-Based Antidiabetic Drug Development Services
• Antibody-Based Antidiabetic Drug Development Services
• Glycan-Based Antidiabetic Drug Development Services
• Nucleic Acid-Based Antidiabetic Drug Development Services
• Vaccine Development Services for Diabetes

• Mouse Models
• Assay Kits
• Antibodies
• Cell Lines & Lysates
• Proteins & Peptides
• Inhibitors & Activators