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Cat. No.: DPP-001233
| Product Overview | |
|---|---|
| Species | Human |
| Expression System | Escherichia coli |
| Format | Liquid |
| Purity | ≥ 95% by SDS-PAGE |
| Nature | Recombinant |
| Target Information | |
|---|---|
| Gene Name | ZNF746 |
| UniProt No. | Q6NUN9 |
| Gene ID | 155061 |
| Alternative Names | PARIS; Parkin-interacting substrate; Zinc finger protein 746; ZN746_HUMAN; ZNF746 |
| Function | Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. |
| Cellular Localization | Cytoplasm. Nucleus. Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes. |
| Protein Length | Full length protein |
| Sequence | AEAVAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEK TAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPG SKGESPKEWGKLEDWQKELYKHVMRGNYETLVSLDYAISKPEVLSQIEQG KEPCNWRRPGPKIPDVPVDPSPGSGPPVPAPDLLMQIKQEGELQLQEQQA LGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTS WQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIKTEVQEEEVVATPVHP TDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARP ERDMGELSPAVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRTGPEGLP YSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGR PFTCATCGKSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGG GSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPCTECEKRFTERS KLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKTPARGQPL PTPPAPPDPFKSPASKGPLASTDLVTDWTCGLSVLGPTDGGDM,Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 4 C2H2-type zinc fingers. Contains 1 KRAB domain. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped on dry ice. |
| Storage | Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
