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Cat. No.: DPP-001162
| Product Overview | |
|---|---|
| Species | Human |
| Expression System | HEK 293 cells |
| Endotoxin Level | < 1.000 Eu/µg |
| Format | Lyophilized |
| Purity | ≥ 95% by SDS-PAGE |
| Nature | Recombinant |
| Target Information | |
|---|---|
| Gene Name | LEPR |
| UniProt No. | P48357 |
| Gene ID | 3953 |
| Molecular Weight | 120 kDa including tags |
| Alternative Names | CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEP-R; LEPR; LEPR_HUMAN; LEPRD; Leptin receptor; Leptin receptor fatty; Leptin receptor gene related protein; Leptin receptor precursor; OB R gene related protein; OB receptor; OB-R; OB-RGRP; obl; Obr |
| Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway. |
| Cellular Localization | Secreted and Cell membrane. |
| Protein Length | Protein fragment |
| Sequence | FNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPK FNSSGTHFSN;LSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLV FQQIDANWNIQCWLKGDLKLFI;CYVESLFKNLFRNYNYKVHLLYVLPE VLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVP;TAKLNDTLLMCLKI TSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPP;LV PFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRL DGPGIWSD;WSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIV PSKEIVWWMNLAEKIPQSQY;DVVSDHVSKVTFFNLNETKPRGKFTYDA VYCCNEHECHHRYAELYVIDVNINISCETDGY;LTKMTCRWSTSTIQSL AESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQ;PIFL LSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK ISWEKP;VFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDL CAVYAVQVRCKRLDGLGY;WSNWSNPAYTVVMDIKVPMRGPEFWRIING DTMKKEKNVTLLWKPLMKNDSLCSVQRYVI;NHHTSCNGTWSEDVGNHT KFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIV;QSLSAY PLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYI HDHF;IPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSD,Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like (immunoglobulin-like) domain. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped on dry ice. |
| Storage | Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
