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Cat. No.: DPP-001200
| Product Overview | |
|---|---|
| Species | Human |
| Expression System | Yeast |
| Format | Liquid |
| Purity | ≥ 80% by SDS-PAGE |
| Nature | Recombinant |
| Target Information | |
|---|---|
| Gene Name | PTK7 |
| UniProt No. | Q13308 |
| Gene ID | 5754 |
| Molecular Weight | 77 kDa including tags |
| Alternative Names | 8430404F20Rik; CCK 4; CCK-4; Colon carcinoma kinase 4; Human colon carcinoma kinase 4 (CCK4) mRNA complete cds; Inactive tyrosine-protein kinase 7; mPTK7/CCK4; OTTHUMP00000217016; Protein tyrosine kinase PTK 7; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK 7; PTK7; PTK7 protein tyrosine kinase; PTK7 protein tyrosine kinase 7; PTK7_HUMAN; Serum response factor; Srf; Tyrosine-protein kinase-like 7 |
| Function | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
| Cellular Localization | Membrane. Cell junction. Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. |
| Protein Length | Protein fragment |
| Sequence | AIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFA QGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVV LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLA PQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATV FANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEP RVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLAN IAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGY LDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGRE KPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQI RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDR ILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLY VVDKPVPEESEGPGSPPPYKMIQT,Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped on dry ice. |
| Storage | Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
