Cat. No.: DAB-0012963
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Reactivity | Mouse |
| Applications | WB |
| Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro25 of mouse xCT/SLC7A11 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | Slc7a11 |
| UniProt No. | Q9WTR6 |
| Gene ID | 26570 |
| Gene Description | The x cysteine/glutamate antiporter consists of a light chain subunit that confers substrate specificity and a glycosylated heavy chain subunit located on the cell surface. The heterodimeric amino acid transport system x provides selective import of cysteine into cells in exchange for glutamate and regulating intracellular glutathione levels, which is essential for cellular protection from oxidative stress. Research studies have shown that xCT expression increases in various tumors, including gliomas, and have implicated xCT in GSH-mediated anticancer drug resistance. Researchers have found that xCT provides neuroprotection by enhancing glutathione export from non-neuronal cells. Moreover, investigators identified xCT as the fusion-entry receptor for Kaposi's sarcoma-associated herpesvirus. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
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