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Cat. No.: DAB-0012957
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Monkey |
| Applications | WB, IP |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His356 of human WDR59 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | WDR59 |
| UniProt No. | Q6PJI9 |
| Gene ID | 79726 |
| Gene Description | The mTORC1 kinase complex plays a critical role in cell growth regulation. mTORC1 activity is modulated by cellular environmental factors, which are mediated through a protein complex known as GATOR. GATOR is comprised of two protein subcomplexes, that function in opposing fashion to regulate mTORC1 activity. WDR59 was identified as a component of the GATOR2 subcomplex, that functions to positively regulate mTORC1 activity. Conversely, the GATOR1 subcomplex, negatively regulates mTORC1 activity, through activation of RagA and RagB GTPases. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
