Rabbit VDAC2 Polyclonal Antibody

Rabbit VDAC2 Polyclonal Antibody

Cat. No.: DAB-0012955

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Host Species Rabbit
Reactivity Human, Mouse, Rat
Applications WB
Product Description Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the central sequence of human VDAC2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Format Liquid
Purity Affinity purity
Target Information
Target Name VDAC2
UniProt No. P45880
Gene ID 7417
Gene Description Voltage-dependent anion channel, ubiquitously expressed and located in the outer mitochondrial membrane, is generally thought to be the primary means by which metabolites diffuse in and out of the mitochondria. In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics. Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c. In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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