Rabbit UPF2 (D3B10) Monoclonal Antibody

Rabbit UPF2 (D3B10) Monoclonal Antibody

Cat. No.: DAB-0012949

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse, Rat, Monkey
Applications WB
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu391 of human UPF2 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name UPF2
UniProt No. Q9HAU5
Gene ID 26019
Gene Description UPF1 was identified as an active component in nonsense-mediated mRNA decay, an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons. UPF1 was found to be an ATP-dependent RNA helicase in the cytoplasm and was later shown to be a component of cytoplasmic P-bodies. UPF1 phosphorylation mediates the repression of translation that accompanies NMD, allowing mRNA accessibility to the NMD machinery. Two other active components of NMD, UPF2 and UPF3, were also identified and described as having perinuclear and nucleocytoplasmic localization, respectively.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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