Rabbit Tuberin/TSC2 (phospho Ser664) (D3B9Z) Monoclonal Antibody

Rabbit Tuberin/TSC2 (phospho Ser664) (D3B9Z) Monoclonal Antibody

Cat. No.: DAB-0012668

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human
Applications WB, IP
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser664 of human Tuberin/TSC2 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name TSC2
UniProt No. P49815
Gene ID 7249
Gene Description Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development. Mutations in either TSC2 or the related TSC1 gene cause tuberous sclerosis complex, an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. Tuberin is directly phosphorylated at Thr1462 by Akt/PKB. Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity. In addition, tuberin inhibits the mammalian target of rapamycin, which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1, and eventual inhibition of translation.p44/42 MAPK phosphorylates of TSC2 at Ser664 which leads to TSC1-TSC2 dissociation and considerably decreases the ability of TSC2 to inhibit mTOR signaling,  cell proliferation and oncogenic transformation. Furthermore, studies have indicated that cancer patients with TSC2 phosphorylation at Ser664 may benefit from MAPK and mTOR inhibitors.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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