Rabbit TCF11/NRF1 (D5B10) Monoclonal Antibody

Rabbit TCF11/NRF1 (D5B10) Monoclonal Antibody

Cat. No.: DAB-0012882

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse, Monkey
Applications WB
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly129 of human TCF11 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name NFE2L1
UniProt No. Q14494
Gene ID 4779
Gene Description Transcription factor 11 is a basic leucine zipper transcription factor. It is also referred to as Nuclear factor E2-related factor 1. TCF11 was initially reported to activate erythroid-specific, human globin gene expression. It plays an essential role during embryonic development. It also associates with other transcription factors, such as Jun proteins, to transcriptionally control antioxidant response element -mediated expression in response to antioxidants and xenobiotics. TCF11 has been shown to regulate proteasomal degradation and mediate the proteasome recovery pathway after proteasome inhibition. TCF11 is ubiquitously expressed and several isoforms have been reported. The 120 kDa form exists in the endoplasmic reticulum membrane under normal conditions. Upon proteasome inhibition, TCF11 translocates to the nucleus. The 65 kDa N-terminal-truncated form is constitutively localized to the nucleus. TCF11 protein levels are regulated by ubiquitination and proteasomal-mediated degradation; proteasome inhibitors stabilize TCF11.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Related Products
logo

Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.

Quick Links
Contact Info
  • 1-516-880-2558
  • 500-A Wheeler Rd, Hauppauge, NY 11788, USA
Copyright © 2024 Ace Therapeutics. All Rights Reserved.
Top

We use cookies to understand how you use our site and to improve the overall user experience. This includes personalizing content and advertising. Read our Privacy Policy

Accept Cookies
x