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Cat. No.: DAB-0012870
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Rat |
| Applications | WB, IP |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human STEAP1 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | STEAP1 |
| UniProt No. | Q9UHE8 |
| Gene ID | 26872 |
| Gene Description | Six transmembrane epithelial antigen of the prostate 1 is a transmembrane protein abundantly expressed in normal prostate epithelial cells. It is a metalloreductase that reduces Fe3+ to Fe2+ and Cu2+ to Cu1+. STEAP1 is also reportedly overexpressed in multiple tumor types, and has been used as a cell surface biomarker for prostate cancer and Ewing's sarcoma. Peptides derived from STEAP1 protein have been shown to induce an antigen-specific cytotoxic T lymphocyte response that can kill tumor cells expressing STEAP1. These finding are the basis for research studies examining the efficacy of antibody-drug conjugates targeting STEAP1. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
