Rabbit SOCS3 Polyclonal Antibody

Rabbit SOCS3 Polyclonal Antibody

Cat. No.: DAB-0011418

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Reactivity Human
Applications IHC-P
Product Description Rabbit polyclonal antibody to SOCS3.
Format Liquid
Purity Affinity purity
Target Information
Target Name SOCS3
UniProt No. O14543
Gene ID 9021
Gene Description SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate recognition component of a SCF-like ECS E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Upon delivery aliquot and store at -20 °C. Avoid freeze / thaw cycles.
Storage Buffer pH: 7.40; Preservative: 0.1% Sodium azide; Constituents: PBS, 1% BSA
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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