Rabbit SMG-1 (Q25) Polyclonal Antibody

Rabbit SMG-1 (Q25) Polyclonal Antibody

Cat. No.: DAB-0012845

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Host Species Rabbit
Reactivity Human, Mouse, Rat, Monkey
Applications WB, IP
Product Description Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino terminal residues of human SMG-1. Antibodies are purifed using protein A and peptide affinity chromatography.
Format Liquid
Purity Affinity purity
Target Information
Target Name SMG1
UniProt No. Q96Q15
Gene ID 23049
Gene Description SMG-1 is a member of the phosphoinositide 3-kinase-related kinase family, which includes ATM, ATR, mTOR, DNA-PKcs, and TRRAP. Activated by DNA damage, SMG-1 has been shown to phosphorylate p53 and hUpf1. hUpf1 is a subunit of the surveillance complex that allows degradation of messenger RNA species containing premature termination codons. This process, known as nonsense-mediated mRNA decay, prevents the translation of truncated forms of proteins that may result in gain of function or dominant negative species. NMD occurs under normal cellular conditions as well as in response to damage. SMG-1 has also been shown to affect cell death receptor signaling and to protect cells from extrinsically induced apoptotic cell death.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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