Rabbit SIRT4 Polyclonal Antibody

Rabbit SIRT4 Polyclonal Antibody

Cat. No.: DAB-0010533

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Reactivity Rat
Applications WB
Product Description Rabbit polyclonal antibody to SIRT4.
Format Liquid
Purity Affinity purity
Target Information
Target Name SIRT4
UniProt No. Q9Y6E7
Gene ID 23409
Gene Description Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD levels. Down-regulates insulin secretion.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Upon delivery aliquot and store at -20 °C or -80 °C. Avoid repeated freeze / thaw cycles.
Storage Buffer Preservative: 0.01% Thimerosal (merthiolate); Constituents: 69% PBS, 0.5% BSA, 30% Glycerol (glycerin, glycerine), 0.15% EDTA
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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