Rabbit Rap1A/Rap1B Polyclonal Antibody

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Cat. No.: DAB-0012787

Size: 20 µL Size: 100 µL Size: Customer Size

Product Information
Clonality	Polyclonal
Host Species	Rabbit
Reactivity	Human, Mouse, Rat, Monkey, Bovine
Applications	WB
Product Description	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln130 of human Rap1A. Antibodies are purified by protein A and peptide affinity chromatography.
Format	Liquid
Purity	Affinity purity

Target Information
Gene Description	Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases, G-protein coupled receptors, death domain associated receptors and ion channels. Like other small GTPases, Rap activity is stimulated by guanine nucleotide exchange factors and inactivated by GTPase activating proteins. A wide variety of Rap GEFs have been identified: C3G connects Rap1 with RTKs through adaptor proteins such as Crk, Epacs transmit signals from cAMP, and CD-GEFs convey signals from either or both Ca2+ and DAG. Rap1 primarily regulates multiple integrin-dependent processes such as morphogenesis, cell-cell adhesion, hematopoiesis, leukocyte migration and tumor invasion. Rap1 may also regulate proliferation, differentiation and survival through downstream effectors including B-Raf, PI3K, RalGEF and phospholipases. Rap1 and Rap2 are not fuctionally redundant as they perform overlapping but distinct functions. Recent research indicates that Rap2 regulates Dsh subcellular localization and is required for Wnt signaling in early development.

Target Information

Gene Description

Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases, G-protein coupled receptors, death domain associated receptors and ion channels. Like other small GTPases, Rap activity is stimulated by guanine nucleotide exchange factors and inactivated by GTPase activating proteins. A wide variety of Rap GEFs have been identified: C3G connects Rap1 with RTKs through adaptor proteins such as Crk, Epacs transmit signals from cAMP, and CD-GEFs convey signals from either or both Ca2+ and DAG. Rap1 primarily regulates multiple integrin-dependent processes such as morphogenesis, cell-cell adhesion, hematopoiesis, leukocyte migration and tumor invasion. Rap1 may also regulate proliferation, differentiation and survival through downstream effectors including B-Raf, PI3K, RalGEF and phospholipases. Rap1 and Rap2 are not fuctionally redundant as they perform overlapping but distinct functions. Recent research indicates that Rap2 regulates Dsh subcellular localization and is required for Wnt signaling in early development.

Shipping & Storage
Shipping	Shipped at 4 °C.
Storage Instructions	Store at –20 °C. Do not aliquot the antibody.
Storage Buffer	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol.

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