Rabbit Pyruvate Carboxylase Polyclonal Antibody

Rabbit Pyruvate Carboxylase Polyclonal Antibody

Cat. No.: DAB-0012777

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Host Species Rabbit
Reactivity Human, Mouse, Rat, Monkey
Applications WB
Product Description Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human pyruvate carboxylase protein. Antibodies are purified by peptide affinity chromatography.
Format Liquid
Purity Affinity purity
Target Information
Target Name PC
UniProt No. P11498
Gene ID 5091
Gene Description Pyruvate carboxylase catalyzes the carboxylation of pyruvate to oxaloacetate in an anaplerotic pathway to replenish TCA cycle intermediates. It is also critical in regulating gluconeogenesis in the liver. Studies show that the increase of PC flux contributes to the induction of hepatic gluconeogenesis by glucagon. In addition, high-fat diet is shown to promote hepatic glucose uptake and induce PC activity in the liver. Loss of hepatic PC prevents diet-induced hyperglycemia and insulin resistance. Furthermore, this enzyme is also required for antioxidant defenses.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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