Rabbit PTPα (phospho Tyr789) Polyclonal Antibody

Rabbit PTPα (phospho Tyr789) Polyclonal Antibody

Cat. No.: DAB-0012627

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Host Species Rabbit
Reactivity Human, Mouse, Rat, Monkey
Applications WB, IP
Product Description Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr789 of human PTPα. Antibodies are purified by protein A and peptide affinity chromatography.
Format Liquid
Purity Affinity purity
Target Information
Target Name PTPRA
UniProt No. P18433
Gene ID 5786
Gene Description PTPα is a transmembrane receptor tyrosine phosphatase implicated in the regulation of Src family kinases during the G2 to mitosis entry point. Two identified splice variants differ in the size of the extracellular region; the shorter form appears to be ubiquitously expressed while the larger protein is more limited in distribution. The cytoplasmic region of PTPα contains two putative catalytic domains. One phosphatase domain exhibits catalytic activity while the other may regulate phosphatase activity by allowing receptor dimer formation. PTPα is a physiological regulator of Src and Src family kinases. Constitutive phosphorylation of the carboxy-terminal Tyr789 of PTPα is essential for dephosphorylation of Src at Tyr527. Phosphorylation of PTPα at this residue also allows binding of the Grb2 inhibitor, restricting PTPα activation of Src. PKC-mediated phosphorylation of the PTP at Ser180 and Ser204 also increases PTPα phosphatase activity.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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