Rabbit PTEN (138G6) Monoclonal Antibody

Rabbit PTEN (138G6) Monoclonal Antibody

Cat. No.: DAB-0012767

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse, Rat, Monkey
Applications WB, IHC
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal sequence of human PTEN.
Format Liquid
Purity Affinity purity
Target Information
Target Name PTEN
UniProt No. P60484
Gene ID 5728
Gene Description PTEN, also referred to as MMAC phosphatase, is a tumor suppressor implicated in a wide variety of human cancers. PTEN encodes a 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase. PTEN is a major negative regulator of the PI3K/Akt signaling pathway. PTEN possesses a carboxy-terminal, noncatalytic regulatory domain with three phosphorylation sites that regulate PTEN stability and may affect its biological activity. PTEN regulates p53 protein levels and activity and is involved in G protein-coupled signaling during chemotaxis.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at -20 °C. This product will freeze at -20 °C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.
Storage Buffer Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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