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Cat. No.: DAB-0012759
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Prdx6 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | PRDX6 |
| UniProt No. | P30041 |
| Gene ID | 9588 |
| Gene Description | Peroxiredoxin 6 belongs to an antioxidant enzyme family of non-seleno peroxidases. It is a unique member of the Prdx family exhibiting both glutathione peroxidase and phospholipase A2 activities. Prdx6 regulates phospholipid turnover as well as protects cells against oxidative injury. Prdx6 is expressed in all major organs with a particularly high level in lung where it regulates lung surfactant phospholipid synthesis and turnover. Studies show Prdx6 is aberrantly expressed in various cancers and promotes cancer cell metastasis and invasion. Elevated expression of Prdx6 and other prdx family members contributes to drug resistance in cancer cells. Prdx6 is also expressed in neutrophils, where it regulates the function of these cells and activates NADPH oxidase . |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
