Cat. No.: DAB-0012757
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PRDX2 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | PRDX2 |
| UniProt No. | P32119 |
| Gene ID | 7001 |
| Gene Description | Peroxiredoxin 2 is a ubiquitously expressed thioredoxin peroxidase. The enzyme catalyzes the reduction of hydrogen peroxide and organic hydroperoxides via the thioredoxin system. An antioxidant, PRDX2 neutralizes endogenous reactive oxygen species and regulates cytokine-induced peroxide levels for normal cell function. Research studies have shown that PRDX2 plays important roles in inflammation, cancer, and natural killer cell activation. During cancer progression, PRDX2 is upregulated and protects cancer cells from oxidative stress-induced apoptosis. In inflammatory diseases such as infection, myocardial infarction, and ischemia, PRDX2 not only protects cells from oxidative stress-induced death, but is also released into extracellular space to trigger local inflammation and to activate NK cells for innate immune response. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
