Rabbit PLCγ2 (E7L6G) Monoclonal Antibody

Rabbit PLCγ2 (E7L6G) Monoclonal Antibody

Cat. No.: DAB-0012734

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse
Applications WB
Product Description Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PLCγ2 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name PLCG2
UniProt No. P16885
Gene ID 5336
Gene Description Phosphoinositide-specific phospholipase C plays a significant role in transmembrane signaling. In response to extracellular stimuli, such as hormones, growth factors, and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4, 5-bisphosphate to generate two secondary messengers: inositol 1, 4, 5-triphosphate and diacylglycerol. At least four families of PLCs have been identified: PLCβ, PLCγ, PLCδ, and PLCε. Phosphorylation is one of the key mechanisms that regulate the activity of PLC. PLCγ is activated by both receptor and non-receptor tyrosine kinases. PLCγ forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLCγ at Tyr771, 783, and 1248. Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCγ1. PLCγ2 is engaged in antigen-dependent signaling in B cells and collagen-dependent signaling in platelets. Phosphorylation by Btk or Lck at Tyr753, 759, 1197, and 1217 is correlated with PLCγ2 activity.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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