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Cat. No.: DAB-0012702
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human |
| Applications | WB, IP |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly290 of human PiT1 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | SLC20A1 |
| UniProt No. | Q8WUM9 |
| Gene ID | 6574 |
| Gene Description | Phosphate transporter 1 is a sodium dependent phosphate transporter that imports Pi into cells. PiT1 was initially identified as a receptor for retroviruses. It is widely expressed in various tissues where it plays a critical role in maintaining cellular Pi homeostasis. Phosphate transporter 1 is important in cell proliferation and tumor cell growth independent of PiT1 phosphate transport function. Researchers have found that PiT1 is involved in TNF-α induced apoptosis. Moreover, phosphate uptake via PiT1 is crucial for vascular calcification and overexpression of PiT1 leads to soft tissue calcification in Werner syndrome patients. Additional research indicates that increased PiT1 expression is seen in calcific aortic valve disease tissues, and that PiT1 enhances apoptosis and mineralization by modifying Akt1 levels. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
