Rabbit PFAS (E4M7R) Monoclonal Antibody

Rabbit PFAS (E4M7R) Monoclonal Antibody

Cat. No.: DAB-0012416

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse, Rat, Monkey
Applications WB
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro399 of human PFAS protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name PFAS
UniProt No. O15067
Gene ID 5198
Gene Description Phosphoribosylformylglycinamidine synthase is a metabolic enzyme associated with a protein complex known as the “purinosome, ” which is involved in de novo purine synthesis. Research studies have shown that activation of the MAPK/ERK pathway leads to downstream activation of PFAS. Specifically, it was shown that PFAS is a substrate of ERK2, which phosphorylates PFAS at Thr619; activation of PFAS results in the de novo generation of purine intermediates required for cell and tumor growth. It has also been reported that both PFAS and viral PFAS-like proteins can activate RIG-I pattern recognition receptors, implicating PFAS-mediated deamidation in the innate immune response to viral infection.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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