Cat. No.: DAB-0012409
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IP, IF |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val274 of human Pdx1 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | PDX1 |
| UniProt No. | P52945 |
| Gene ID | 3651 |
| Gene Description | The pancreatic duodenal homeobox gene-1 is a transcription factor that contributes to pancreas development, pancreatic β-cell differentiation, and mature β-cell function. It plays an essential role in the commitment of endoderm to a pancreatic and later β-cell phenotype. In the mature pancreas, Pdx1 expression is more restricted to the pancreatic β-cells, where it promotes the expression of genes important for β-cell functions such as insulin, glucokinase, and Glut2. Mutations of the corresponding Pdx1 gene may be associated with diabetes and cases of pancreatic insufficiency. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
