Cat. No.: DAB-0012408
Product Information | |
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Clonality | Monoclonal |
Isotype | IgG |
Host Species | Rabbit |
Reactivity | Human, Mouse, Rat, Monkey |
Applications | WB, IP |
Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu327 of human PDP1 protein. |
Format | Liquid |
Purity | Affinity purity |
Target Information | |
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Target Name | PDP1 |
UniProt No. | Q9P0J1 |
Gene ID | 54704 |
Gene Description | Pyruvate dehydrogenase catalyzes decarboxylation of the glycolytic intermediate pyruvate to acetyl-CoA. Acetyl-CoA is further metabolized in the tricarboxylic acid cycle to generate ATP and NADH. Pyruvate dehydrogenase kinase 1 phosphorylates PDH to suppress its activity, while pyruvate dehydrogenase phosphatase 1 dephosphorylates PDH to enhance its activity. Phosphorylation of PDP1 at Tyr94 inhibits PDP1 and has been shown to be present in a variety of cancer cell lines and primary human leukemia cells. |
Shipping & Storage | |
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Shipping | Shipped at 4 °C. |
Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
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