Cat. No.: DAB-0012408
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IP |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu327 of human PDP1 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | PDP1 |
| UniProt No. | Q9P0J1 |
| Gene ID | 54704 |
| Gene Description | Pyruvate dehydrogenase catalyzes decarboxylation of the glycolytic intermediate pyruvate to acetyl-CoA. Acetyl-CoA is further metabolized in the tricarboxylic acid cycle to generate ATP and NADH. Pyruvate dehydrogenase kinase 1 phosphorylates PDH to suppress its activity, while pyruvate dehydrogenase phosphatase 1 dephosphorylates PDH to enhance its activity. Phosphorylation of PDP1 at Tyr94 inhibits PDP1 and has been shown to be present in a variety of cancer cell lines and primary human leukemia cells. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
