Rabbit PARG (D4E6X) Monoclonal Antibody

Rabbit PARG (D4E6X) Monoclonal Antibody

Cat. No.: DAB-0012391

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Monkey
Applications WB, IP
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PARG protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name PARG
UniProt No. Q86W56
Gene ID 670
Gene Description Poly glycohydrolase is an enzyme that hydrolyzes poly formed by members of the PAR polymerase enzyme family. Poly -ribosylation is a post-translational modification that is catalyzed by PARP proteins. This modification involves polymerization of ADP-ribose from NAD+ to target proteins, such as histones and transcription factors, and plays a wide range of biological roles, including the response to DNA damage and transcriptional regulation. The mammalian PARG enzyme that catalyzes the removal of this modification exists as multiple isoforms. PARG isoforms 1-3 shuttle between the nucleus and cytoplasm and are responsible for most of the PARG activity. The smaller isoforms 4 and 5 reside in the cytoplasm. Research studies link altered PAR metabolism to inflammatory and autoimmune diseases, as well as neuronal degeneration. PARG inhibitors that increase PAR levels may sensitize cells to cancer treatments and may help in the development of cancer therapies.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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