Rabbit PANK4 (D6J4R) Monoclonal Antibody

Rabbit PANK4 (D6J4R) Monoclonal Antibody

Cat. No.: DAB-0012386

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse, Rat, Hamster, Monkey
Applications WB
Product Description Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro522 of human PANK4 protein.
Format Liquid
Purity Affinity purity
Target Information
Target Name PANK4
UniProt No. Q9NVE7
Gene ID 55229
Gene Description Panthothenate kinase is an enzyme that is responsible for catalyzing the first step in coenzyme A synthesis. There are four human PANK genes. PANK4 is ubiquitously expressed, but higher expression levels are observed in muscle. PANK4 expression is elevated in rat skeletal muscle under high glucose conditions. There is evidence that rat PANK4 colocalizes with pyruvate kinase M2 in vitro. PANK4 may also play a protective role in beta-cell apoptosis by lowering the levels of pro-caspase-9. Research studies have shown that mutations in the PANK2 gene are associated with Neurodegeneration with Brain Iron Accumulation, formerly known as Hallervorden-Spatz syndrome. Expression of hPANK4 in a Drosophila model of NBIA rescues the phenotype with the exception of infertility.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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