Cat. No.: DAB-0012386
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat, Hamster, Monkey |
| Applications | WB |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro522 of human PANK4 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | PANK4 |
| UniProt No. | Q9NVE7 |
| Gene ID | 55229 |
| Gene Description | Panthothenate kinase is an enzyme that is responsible for catalyzing the first step in coenzyme A synthesis. There are four human PANK genes. PANK4 is ubiquitously expressed, but higher expression levels are observed in muscle. PANK4 expression is elevated in rat skeletal muscle under high glucose conditions. There is evidence that rat PANK4 colocalizes with pyruvate kinase M2 in vitro. PANK4 may also play a protective role in beta-cell apoptosis by lowering the levels of pro-caspase-9. Research studies have shown that mutations in the PANK2 gene are associated with Neurodegeneration with Brain Iron Accumulation, formerly known as Hallervorden-Spatz syndrome. Expression of hPANK4 in a Drosophila model of NBIA rescues the phenotype with the exception of infertility. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
