Rabbit Pancreatic Marker IHC Sampler Kit Monoclonal Antibody

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Cat. No.: DAB-0012383

Size: 20 µL Size: 100 µL Size: Customer Size

Product Information
Clonality	Monoclonal
Host Species	Rabbit
Product Description	Monoclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to Val42 of human insulin, Ala137 of human proglucagon, residues near the carboxy terminus of human Pax6, and to human CD200 recombinant protein. Pan-Keratin (C11) Mouse mAb (isotype: IgG1) is produced by immunizing a BALB/c mouse with a cytoskeleton preparation from A-431 cells. Polyclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to the sequence of human glucagon, and the sequence of human C-peptide. Antibodies are purified by protein A and peptide affinity chromatography.
Format	Liquid
Purity	Affinity purity

Target Information
Gene Description	Insulin is a hormone that is produced and released from pancreatic β cells through a glucose sensing pathway. Proinsulin is the precursor molecule to insulin and is processed prior to its secretion. Insulin is composed of A-peptide and B-peptide which are joined by a disulfide bond. The center one-third of the molecule is cleaved and released as C-peptide, which has a longer half-life than insulin. Antibodies to both insulin and C-peptide are useful markers for β cells.Glucose homeostasis is regulated by a variety of hormones including glucagon. Glucagon is synthesized as the precursor molecule proglucagon and is proteolytically processed to yield the mature peptide in α cells of the pancreatic islets. Glucagon causes the release of glucose from glycogen and stimulates gluconeogenesis in the liver. Antibodies to glucagon and proglucagon are useful markers for pancreatic α cells.NKX6.1 is an important transcription factor in a network of transcription factors that are critical for pancreatic β cell development and maintenance. Antibodies to NKX6.1 are useful markers for β cells.Pan-Keratin and CD200 antibodies are useful to mark and differentiate some pancreatic tumor subtypes. Pan-Keratin antibodies mark epithelial cells in pancreatic adenocarcinomas while CD200 is a useful marker for neuroendocrine pancreatic tumors.

Target Information

Gene Description

Insulin is a hormone that is produced and released from pancreatic β cells through a glucose sensing pathway. Proinsulin is the precursor molecule to insulin and is processed prior to its secretion. Insulin is composed of A-peptide and B-peptide which are joined by a disulfide bond. The center one-third of the molecule is cleaved and released as C-peptide, which has a longer half-life than insulin. Antibodies to both insulin and C-peptide are useful markers for β cells.Glucose homeostasis is regulated by a variety of hormones including glucagon. Glucagon is synthesized as the precursor molecule proglucagon and is proteolytically processed to yield the mature peptide in α cells of the pancreatic islets. Glucagon causes the release of glucose from glycogen and stimulates gluconeogenesis in the liver. Antibodies to glucagon and proglucagon are useful markers for pancreatic α cells.NKX6.1 is an important transcription factor in a network of transcription factors that are critical for pancreatic β cell development and maintenance. Antibodies to NKX6.1 are useful markers for β cells.Pan-Keratin and CD200 antibodies are useful to mark and differentiate some pancreatic tumor subtypes. Pan-Keratin antibodies mark epithelial cells in pancreatic adenocarcinomas while CD200 is a useful marker for neuroendocrine pancreatic tumors.

Shipping & Storage
Shipping	Shipped at 4 °C.
Storage Instructions	Store at +4 °C short term (1-2 weeks). Store at -20 °C long term.
Storage Buffer	Constituent: 100% PBS

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.