x
- Home
- About Diabetes
- Services
- Diabetes Mellitus Modeling Solutions
- R&D Services for Diabetes Mellitus and Diabetic Complications
- By Drug Development Process
- About Us
- Careers
- Contact Us
Cat. No.: DAB-0012352
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IP |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala211 of human NPRL2 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | NPRL2 |
| UniProt No. | Q8WTW4 |
| Gene ID | 10641 |
| Gene Description | The mTORC1 kinase complex plays a critical role in cell growth regulation. mTORC1 activity is modulated by cellular and environmental factors. Amino acid sensing is mediated through several protein complexes, including GATOR. GATOR is composed of two protein subcomplexes that function in opposing fashion to regulate mTORC1 activity. NPRL2 was identified as a component of the GATOR1 subcomplex that functions to negatively regulate mTORC1 activity through activation of RagA and RagB GTPases. Conversely, the GATOR2 subcomplex positively regulates mTORC1 activity. In addition, NPRL2, also known as TUSC4, has been shown to prevent the degradation of tumor suppressor BRCA1. Overexpression of TUSC4 protein inhibits proliferation of breast cancer cells. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
