Cat. No.: DAB-0012351
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Reactivity | Human |
| Applications | WB, IP |
| Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to central residues of human NPC1L1 protein. Antibodies were purified by protein A and peptide affinity chromatography. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | NPC1L1 |
| UniProt No. | Q9UHC9 |
| Gene ID | 29881 |
| Gene Description | Niemann-Pick C1-like 1 is a transmembrane protein that plays a critical role in cholesterol absorption. It is highly expressed in small intestine and localized along the brush border in both human and mouse epithelial cells. NPC1L1 mediates cholesterol uptake via vesicular endocytosis. Ezetimibe, a potent cholesterol absorption inhibitor used to treat hypercholesterolemia, inhibits cholesterol uptake by preventing NPC1L1 from incorporating into clathrin-coated vesicles. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
