Rabbit NF-kB p65 Monoclonal Antibody

Rabbit NF-kB p65 Monoclonal Antibody

Cat. No.: DAB-0011341

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Monoclonal
Isotype IgG
Host Species Rabbit
Reactivity Human, Mouse
Applications ICC, IF
Product Description Rabbit monoclonal antibody [E379] to NF-kB p65.
Format Liquid
Purity Affinity purity
Target Information
Target Name RELA
UniProt No. Q04206
Gene ID 5970
Gene Description NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at +4 °C short term (1-2 weeks). Upon delivery aliquot. Store at -20 °C. Stable for 12 months at -20 °C. Store In the Dark.
Storage Buffer pH: 7.40; Preservative: 0.02% Sodium azide; Constituents: 30% Glycerol (glycerin, glycerine), 1% BSA, PBS
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