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Cat. No.: DAB-0012314
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human |
| Applications | WB, IP |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ND3 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | MT-ND3 |
| UniProt No. | P03897 |
| Gene ID | 4537 |
| Gene Description | Mitochondrially encoded NADH dehydrogenase 3 is encoded by the mitochondrial gene MT-ND3 and is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase. Located in the mitochondrial inner membrane, Complex I is the largest of the five respiratory complexes and catalyzes electron transfer from NADH to ubiquinone. The mitochondrially encoded subunits of Complex I, including MT-ND3, are the most hydrophobic subunits and form the core of the transmembrane region. Pathogenic variants of the MT-ND3 gene are known to cause mitochondrial complex I deficiency and may lead to a wide range of clinical disorders, including Leigh syndrome, Leber hereditary optic neuropathy, and encephalopathy. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. |
Ace Therapeutics has a team of experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
