Cat. No.: DAB-0012253
| Product Information | |
|---|---|
| Clonality | Monoclonal |
| Isotype | IgG |
| Host Species | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IF |
| Product Description | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MAP7 protein. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | MAP7 |
| UniProt No. | Q14244 |
| Gene ID | 9053 |
| Gene Description | MAP7 is a member of the Microtubule-Associated Proteins that regulates the stability and function of the cytoskeleton in cells. MAP7 facilitates the transport of organelles, such as mitochondria and lysosomes, via recruitment of kinesin-1. This role of MAP7 in organelle transport occurs in neuronal and non-neuronal cells, including Drosophila oocytes, and in S2 cells and mammalian muscle cells. In addition to promoting organelle transport via kinesin-1 recruitment, MAP7 also contributes to the morphogenesis of axons that is domain-specific, whereas the full-length MAP7 promotes branch maturation, N- and P- domains are responsible for branch formation, and the C-terminal kinesin-interacting domain contributes to the axonal growth. MAP7 and the paralog MAP7D1 directly interact with disheveled, an effector of the Wnt5a β-catenin-independent pathway, regulating the microtubule remodeling, cell migration, and cell adhesion in HeLa cells. MAP7 is considered a biomarker in a model to treat multiple sclerosis based on the tolerogenic dendritic cells induced by vitamin D3. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. |
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