Rabbit LAT1 Polyclonal Antibody

Rabbit LAT1 Polyclonal Antibody

Cat. No.: DAB-0012220

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Host Species Rabbit
Reactivity Human
Applications WB, IP
Product Description Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues at the amino terminus of human LAT1 protein. Antibodies were purified by protein A and peptide affinity chromatography.
Format Liquid
Purity Affinity purity
Target Information
Target Name SLC7A5
UniProt No. Q01650
Gene ID 8140
Gene Description L-type amino acid transporter 1, also known as solute carrier family 7 member 5, is a high-affinity neutral transporter of larger amino acids. It facilitates the cellular amino acid uptake in a sodium independent manner and selectively transports D-and L-isomers of small neutral amino acids. LAT1 also regulates amino acid exchange in conjunction with solute carrier family 1 member 5. Transport of thyroid hormones across the placenta is established via LAT1 during normal fetal development. LAT1 promotes neuronal cell proliferation by regulating the transport of amino acids across the blood brain barrier. LAT1 is upregulated in various cancer types, including breast cancer, lung cancer, prostate cancer, and gliomas. High expression of LAT1 is detected in non-small cell lung cancer with lymph node metastases. Increased LAT1 expression is a novel biomarker of high grade malignancy in prostate cancers. Inhibition of LAT1 suppresses tumor cell growth in several tumor types.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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