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Cat. No.: DAB-0012211
| Product Information | |
|---|---|
| Clonality | Polyclonal |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB |
| Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LACTB protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Format | Liquid |
| Purity | Affinity purity |
| Target Information | |
|---|---|
| Target Name | LACTB |
| UniProt No. | P83111 |
| Gene ID | 114294 |
| Gene Description | LACTB is a serine beta-lactamase-like protein that is most prominently expressed in skeletal muscle, heart and liver. It contains an amino-terminal transmembrane domain and is localized to the mitochondrial intermembrane space, where it is polymerized into stable filaments that promote intramitochondrial membrane organization and micro-compartmentalization. Studies in multiple breast cancer cell types have shown that LACTB can function as a tumor suppressor by promoting decreased levels of phosphatidylserine decarboxylase, leading to reduced cell proliferation. In accordance with this, levels of LACTB have been shown to be downregulated in hepatocellular carcinoma and colorectal cancer and associated with poor prognosis in both. |
| Shipping & Storage | |
|---|---|
| Shipping | Shipped at 4 °C. |
| Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
Ace Therapeutics has a team of wellknown experts in the field of endocrine and metabolic research, aiming to provide innovative preclinical contract research solutions to cope with diabetes and its complications. We provide customized solutions and technical support, enabling the transformation of promising concepts into innovative treatments, thus accelerating the drug development process of diabetes.
