Rabbit IRGM (Rodent Specific) Polyclonal Antibody

Rabbit IRGM (Rodent Specific) Polyclonal Antibody

Cat. No.: DAB-0012196

Size: 20 µL Size: 100 µL Size: Customer Size
Product Information
Clonality Polyclonal
Host Species Rabbit
Reactivity Mouse, Rat
Applications WB
Product Description Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg215 of mouse IRGM protein. Antibodies are purified by protein A and peptide affinity chromatography.
Format Liquid
Purity Affinity purity
Target Information
Target Name Irgm1
UniProt No. Q60766
Gene ID 15944
Gene Description Immunity-related GTPase family M protein 1 belongs to the p47 family of immunity related guanosine triphosphatases that regulate innate immune responses to intracellular pathogens. Research studies indicate that IRGM plays a role in autophagy during clearance of intracellular bacteria. Expression of IRGM in mice, but not in humans, is induced by inflammatory signals that include interferon and LPS. Polymorphisms in the corresponding IRGM gene are associated with some cases of tuberculosis, Crohn’s disease, and severe sepsis. Additional studies indicate that IRGM functions through regulation of autophagy. Mitochondrial IRGM plays a role in mitochondrial fission, membrane polarization, and mitophagy. Knockout mice for IRGM show increased susceptibility to infection as well as intestinal inflammation and Paneth cell abnormalities. Knockout mice against IRGM are also resistant to neuronal autophagy following stroke. RNA viruses commonly target IRGM in order to suppress autophagy and enhance infection.
Shipping & Storage
Shipping Shipped at 4 °C.
Storage Instructions Store at –20 °C. Do not aliquot the antibody.
Storage Buffer Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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