Cat. No.: DAB-0012528
Product Information | |
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Clonality | Polyclonal |
Host Species | Rabbit |
Reactivity | Human, Mouse, Rat |
Applications | WB |
Product Description | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser1756 of rat IP3 receptor. Antibodies are purified by peptide affinity chromatography. |
Format | Liquid |
Purity | Affinity purity |
Target Information | |
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Target Name | ITPR1 |
UniProt No. | Q14643 |
Gene ID | 3708 |
Gene Description | Inositol 1, 4, 5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors that require the second messenger inositol 1, 4, 5-triphosphate for activation. Four individual subunits homo- or hetero-oligomerize to form the receptor's functional channel. Phosphorylation of IP3R1 at Ser1756 by cyclic AMP-dependent protein kinase A regulates the sensitivity of IP3R1 to IP3 and may be a mode of regulation for Ca2+ release. IP3R1-mediated Ca2+ release appears to have an effect on the induction of long term depression in Purkinje cells. |
Shipping & Storage | |
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Shipping | Shipped at 4 °C. |
Storage Instructions | Store at –20 °C. Do not aliquot the antibody. |
Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. |
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